Conference Proceedings
Additive and multiplicative gene-environment interactions for colorectal cancer risk.
Mengmenq Du, Sonja I Berndt, Hermann Brenner, Bette J Caan, Peter T Campbell, Graham Casey, Andrew Chan, Jenny Chang-Claude, Stephen J Chanock, Nilanjan Chatterjee, David V Conti, David Duggan, Jane C Figueiredo, Steven Gallinger, Jian Gong, Robert W Haile, Tabitha A Harrison, Richard B Hayes, Michael Hoffmeister, John L Hopper Show all
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2013
Abstract
Abstract Background: Genetic and environmental factors influence colorectal cancer (CRC) risk. Previous studies have provided additional etiologic insight by examining multiplicative gene-environment interactions for individual susceptibility loci. However, individual loci confer only modest risks, which may limit statistical power and clinical significance. A genetic risk score comprising known CRC loci may provide a more comprehensive assessment of risk. Further, there is a paucity of data on the role of additive gene-environment interactions, which may have greater public health implications than multiplicative interactions. We thus evaluated both additive and multiplicativ..
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